BDBM3033 3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile::CHEMBL302449::Go 6976::Indolocarbazole deriv.

SMILES Cn1c2ccccc2c3c1c4c(c5ccccc5n4CCC#N)c6c3C(=O)NC6

InChI Key InChIKey=VWVYILCFSYNJHF-UHFFFAOYSA-N

Data  5 KI  26 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 3033   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Albert-Ludwigs-University of Freiburg

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 78nMAssay Description:Inhibition of Aurora-B (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 118nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 67nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Mouse)
Tumor Biology Center

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 1.00E+4nMAssay Description:The activity of TPK is measured by its ability to transfer 32P from [gamma-32P]ATP to Poly(Glu,Tyr; 4:l).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Tumor Biology Center

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 5.80E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 20nMAssay Description:In vitro for inhibitory activity against protein kinase C from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 446nMAssay Description:Inhibition of PKCdelta by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro for inhibitory activity against cAMP-dependent protein kinase from bovine heart (A-kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetcGMP-dependent protein kinase 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 6.20E+3nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetProtein kinase C beta type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PKCbeta1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 62nMAssay Description:Inhibition of PKD1 assessed as HDAC5 neuclear exportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PKCalpha by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 27nMAssay Description:Inhibition of PKD1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Mouse)
Tumor Biology Center

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 1.00E+4nMAssay Description:The activity of TPK is measured by its ability to transfer 32P from [gamma-32P]ATP to Poly(Glu,Tyr; 4:l).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetcGMP-dependent protein kinase 1(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 6.20E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 1.00E+5nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetProtein kinase C beta type(Rat)
Tumor Biology Center

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 20nMAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 5.80E+3nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataKi:  3.40nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Abbott Laboratories

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataKi: >8.00E+3nM ΔG°: >-6.88kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataKi: >1.60E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Abbott Laboratories

LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataKi: >1.90E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed