BDBM292797 US10105367, Example 82::US10376514, Example 82

SMILES c1cc(ccc1CN2c3c(c4c(s3)CCCC4)-c5ncnn5C2=O)Cl

InChI Key InChIKey=SRUIZVZXCPBTGE-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 292797   

LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 550nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 370nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of PDE2A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE9A2 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 460nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human PDE7A1 (122-end residues) expressed in Baculovirus infected Sf9 insect cells assessed as decrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMed
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 550nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)