BDBM28582 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine::CHEMBL6616::DOI::DOI,(+)::DOI,(-)::US20240166618, Compound DOI::[125I]2,5-dimethoxy-4-iodoamphetamine::[125I]4-iodo-2,5-dimethoxyphenylisopropylamine::[125I]DOI

SMILES COc1cc(CC(C)N)c(OC)cc1I

InChI Key InChIKey=BGMZUEKZENQUJY-UHFFFAOYSA-N

Data  65 KI  4 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 74 hits for monomerid = 28582   

TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataEC50:  2.90E+5nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2011
Entry Details
PCBioAssay
TargetAmine oxidase [flavin-containing] A(Rat)
Universidad De Chile

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataEC50:  6.30nMT: 2°CAssay Description:Partial agonist activity at human 5-HT2A receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at roo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataEC50:  46nMT: 2°CAssay Description:Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at roo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataEC50:  178nMAssay Description:Agonist activity at rat 5-HT2C receptor expressed in African clawed frog oocytes assessed as increase in current amplitudeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataEC50:  57nMAssay Description:Agonist activity at rat 5-HT2A receptor expressed in African clawed frog oocytes assessed as increase in current amplitudeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.460nMAssay Description:Binding activity against cloned human 5-hydroxytryptamine 2A receptor using [125I]DOI as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.650nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]DOB from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]DOI from recombinant human 5HT2A expressed in Syrian hamster AV12 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  0.930nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  1.41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  1.58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  1.82nMAssay Description:Binding activity against cloned human 5-hydroxytryptamine 2C receptor using [125I]DOI as the radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I](+/-)-DOI from human 5HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  2.36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  2.51nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  3.01nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  5.37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  7.08nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  7.94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  8.32nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  9.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]INBMeO from human 5HT2A receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  14.5nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2C(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  18.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  19nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor of rat frontal cortex using [3H]ketanserin radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  19.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  20.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  26.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  26.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
LigandPNGBDBM28582([125I]2,5-dimethoxy-4-iodoamphetamine | DOI,(-) | ...)
Affinity DataKi:  26.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
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