BDBM28361 N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide::cyclohexyl benzamide derivative, 1

SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@H](CC1)c1cccnc1)C(F)(F)F

InChI Key InChIKey=FLRYWTWLHWACRP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 28361   

LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 124nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed