BDBM27714 5-fluoro-1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-1,2,3,4-tetrahydroquinazoline-2,4-dione::CHEMBL361054::quinazolidinone analogue, 2b

SMILES c1ccc(cc1)C2=CC[N@@](CC2)CCCCN3c4cccc(c4C(=O)NC3=O)F

InChI Key InChIKey=PNPFDRCIGCUCMN-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27714   

TargetPoly [ADP-ribose] polymerase 1(Human)
Fujisawa Pharmaceutical

LigandPNGBDBM27714(CHEMBL361054 | 5-fluoro-1-[4-(4-phenyl-1,2,3,6-tet...)
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP enzyme assay was carried out in reaction mixture consisting of activated salmon teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Fujisawa Pharmaceutical

LigandPNGBDBM27714(CHEMBL361054 | 5-fluoro-1-[4-(4-phenyl-1,2,3,6-tet...)
Affinity DataIC50: 83nMT: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP enzyme assay was carried out in reaction mixture consisting of activated salmon teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Fujisawa Pharmaceutical

LigandPNGBDBM27714(CHEMBL361054 | 5-fluoro-1-[4-(4-phenyl-1,2,3,6-tet...)
Affinity DataIC50: 60nMAssay Description:In vitro inhibitory concentration against human recombinant Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)