BDBM26479 4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine::pyrimidine, 5a

SMILES COc1cc(Nc2nccc(Nc3ccc4c(C)n[nH]c4c3)n2)cc(OC)c1OC

InChI Key InChIKey=SQQAPOSROFWHIB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26479   

LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50: 6.30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human N-terminal His6-tagged BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by chromatography me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed