BDBM25980 BMCL18324 Compound 3::CHEMBL270164::N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide::biphenyl amide, 3

SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N

InChI Key InChIKey=PMMLSQFPBFKLHH-UHFFFAOYSA-N

Data  6 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 25980   

TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nM ΔG°:  -8.93kcal/mole IC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nM ΔG°:  -8.93kcal/mole IC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2008
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi:  240nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi: >4.00E+3nM ΔG°: >-7.28kcal/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed
LigandPNGBDBM25980(N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-ox...)
Affinity DataKi: >5.40E+3nM ΔG°: >-7.11kcal/mole IC50: 1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2008
Entry Details Article
PubMed