BDBM25762 CHEMBL471::N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide::SOTALOL HYDROCHLORIDE::Sotalol::Sotalol,(+)::Sotalol,(-)::cid_66245

SMILES CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI Key InChIKey=ZBMZVLHSJCTVON-UHFFFAOYSA-N

Data  6 KI  15 IC50  5 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 25762   

TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKd:  141nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.93E+5nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 7.20E+3nMAssay Description:Tested for Beta adrenergic receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 7.20E+3nMAssay Description:Concentration effective against displacing [3H]dihydroalprenolol from beta adrenergic receptor from canine ventricular tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2018
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKd:  580nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKd:  580nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 9.00E+3nMAssay Description:In vitro Beta-1 adrenergic receptor affinity in partially purified membrane fractions from canine cardiac tissue using [SH]dihydroalprenolol (4.5 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 8.90E+3nMAssay Description:Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 1.02E+6nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro Beta-2 adrenergic receptor affinity in partially purified membrane fractions from canine lung tissue using [SH]dihydroalprenolol (4.5 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 5.20E+3nMAssay Description:Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataIC50: 9.00E+3nMAssay Description:Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKd:  8.91E+3nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKd:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Niigata College of Pharmacy

Curated by PDSP Ki Database
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi:  339nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetAlbumin(Human)
Molecular Discovery

Curated by ChEMBL
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi:  354nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi:  1.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2011
Entry Details
PubMed
TargetBeta-1 adrenergic receptor(Rat)
Niigata College of Pharmacy

Curated by PDSP Ki Database
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi:  2.24E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Niigata College of Pharmacy

Curated by PDSP Ki Database
LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

LigandPNGBDBM25762(Sotalol,(-) | CHEMBL471 | cid_66245 | Sotalol,(+) ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2011
Entry Details
PubMed