BDBM25226 2,4-Pyrimidine derivative, 28::4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-methanesulfonylphenyl)pyrimidine-2,4-diamine

SMILES CS(=O)(=O)c1cccc(c1)Nc2nccc(n2)Nc3c(ccc4c3OCO4)Cl

InChI Key InChIKey=QTFCKBFCXDAZIU-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25226   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 90nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 90nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 190nMAssay Description:Inhibition of Myc-His-tagged EphB4 expressed in CHOK1 cells assessed as phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 25nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 187nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25226(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-(3-meth...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed