BDBM251588 US9453031, 11

SMILES CNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O

InChI Key InChIKey=JEWXHIMACGOZFL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 251588   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 1.90E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetSerine/threonine-protein kinase mTOR [1360-2549](Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 604nMpH: 7.5 T: 2°CAssay Description:The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 1.51E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 4.00E+6nMAssay Description:Predictor hERG Assay test kits were obtained from Invitrogen (Carlsbad, Calif.). The binding assay was carried out according to the kit instructions....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetCytochrome P450 1A2(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetCytochrome P450 2C19(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 3.40E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: 3.90E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent