BDBM25115 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(pyrrolidin-1-yl)butyl]carbamoyl}amino)-1,2-thiazole-4-carboxamide::CHEMBL253969::CP 547632::CP547632, 24::US9446026, 1

SMILES c1c(cc(c(c1F)COc2c(c(sn2)NC(=O)NCCCCN3CCCC3)C(=O)N)F)Br

InChI Key InChIKey=HXHAJRMTJXHJJZ-UHFFFAOYSA-N

Data  4 KI  28 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 25115   

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 11.1nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetVascular endothelial growth factor receptor 1(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 122nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 419nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetVascular endothelial growth factor receptor 3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 54.2nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetTyrosine-protein kinase Fyn(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 161nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.27nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 3.12E+3nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.86E+3nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetAngiopoietin-1 receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 10.1nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 500nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 24nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataKd:  422nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant TIE2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human recombinant Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 6nMAssay Description:Inhibition of VEGFR2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 11nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 33.9nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 3.08nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 8.5nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetAurora kinase B(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 207nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetVascular endothelial growth factor A(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 5.27nMAssay Description:Inhibition of VEGF-stimulated VEGFR-2 autophosphorylation in intact cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetInsulin receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of recombinant IR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetEpidermal growth factor receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of recombinant EGFR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of recombinant PDGFR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 8.79nMAssay Description:Inhibition of recombinant FGFR-2 tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 10.6nMAssay Description:Inhibition of recombinant VEGFR-2 tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 89nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 54nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataKi:  120nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Abbott Laboratories

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.34kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataKi: >2.00E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Abbott Laboratories

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.34kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed