BDBM244605 US10226449, cpd 214::US9428502, 214

SMILES Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C2CCOC2)nc1C#N

InChI Key InChIKey=BNNIAZIWRMSHBX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244605   

TargetGenome polyprotein(HCV)
3-V Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244605BDBM244605(US9428502, 214 | US10226449, cpd 214 | US202500179...)
Affinity DataEC50:  6nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244605BDBM244605(US9428502, 214 | US10226449, cpd 214 | US202500179...)
Affinity DataIC50: 14nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244605BDBM244605(US9428502, 214 | US10226449, cpd 214 | US202500179...)
Affinity DataIC50: 14nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244605BDBM244605(US9428502, 214 | US10226449, cpd 214 | US202500179...)
Affinity DataIC50: 14nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent