BDBM23981 (2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine::1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride::CHEMBL30294::Tetrahydronaphthalen-2-amine, 3a

SMILES NC1CCc2ccccc2C1

InChI Key InChIKey=LCGFVWKNXLRFIF-UHFFFAOYSA-N

Data  6 KI  4 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 23981   

TargetCytosol aminopeptidase(Bovine)
Enscmu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataIC50: 1.00E+6nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
Enscmu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataIC50: 1.00E+6nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Enscmu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Enscmu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataEC50: >3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKd:  2.45E+3nMAssay Description:The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  6.80E+3nMAssay Description:The compound was tested for In vitro inhibitory activity against Phenylethanolamine N-Methyltransferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  1.11E+4nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to phenylethanolamine N-methyltransferase(PNMT) in bovineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataKi:  3.98E+4nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed