BDBM23722 4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole::N-Benzoylpyrazole deriv., 30

SMILES Cc1nn(C(=O)c2ccc(Cl)cc2)c(C)c1Cl

InChI Key InChIKey=NTPKEXXMJVFTKE-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 23722   

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 4.70E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetEctonucleoside triphosphate diphosphohydrolase 1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of rat NTPDase1 expressed in CHO cells using ATP as substrate preincubated for 10 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 630nMAssay Description:Inhibition of human NPP3 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 910nMAssay Description:Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 5.34E+3nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  1.07E+4nM ΔG°:  -6.78kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed