BDBM23222 Oxalamic acid::Oxamate::Oxamate, 3::Oxamidic Acid::carbamoylformic acid

SMILES C(=O)(C(=O)O)N

InChI Key InChIKey=SOWBFZRMHSNYGE-UHFFFAOYSA-N

Data  5 KI  14 IC50

PDB links: 65 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 23222   

TargetL-lactate dehydrogenase B chain(Bovine)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 1.23E+5nMpH: 7.0 T: 2°CAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/11/2008
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetL-lactate dehydrogenase B chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 3.38E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/13/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/13/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/27/2016
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase B chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 3.38E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/27/2016
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetL-lactate dehydrogenase C chain(Mouse)
Instituto Politécnico Nacional

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMpH: 7.4Assay Description:Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/23/2017
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetL-lactate dehydrogenase B chain(Mouse)
Instituto Politécnico Nacional

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 6.00E+4nMpH: 7.4Assay Description:Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/23/2017
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase A chain(Mouse)
Instituto Politécnico Nacional

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 8.00E+4nMpH: 7.4Assay Description:Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/23/2017
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase(Bovine)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 1.16E+5nMAssay Description:Enzyme assay using recombinant pfLDH and mLDH (bovine heart).More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetL-lactate dehydrogenase(malaria parasite P. falciparum)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 9.44E+4nMAssay Description:Enzyme assay using recombinant pfLDH and mLDH (bovine heart).More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/3/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetMalate dehydrogenase, cytoplasmic(Pig)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+6nMAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/11/2008
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMalate dehydrogenase, mitochondrial(Pig)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+6nMAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/11/2008
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetL-lactate dehydrogenase(malaria parasite P. falciparum)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+6nMAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/11/2008
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetL-lactate dehydrogenase(Plasmodium falciparum)
University of Mississippi

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataIC50: 9.25E+4nMpH: 7.0 T: 2°CAssay Description:LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/11/2008
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataKi:  2.60E+4nMAssay Description:Inhibition of human LDH-AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase B chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataKi:  9.44E+4nMAssay Description:Competitive inhibition of human LDH1 in presence of NADHMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/1/2017
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataKi:  1.36E+5nMAssay Description:Competitive inhibition of human LDH5 in presence of NADHMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/1/2017
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataKi:  1.38E+5nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/24/2011
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL

LigandBDBM23222(carbamoylformic acid | Oxalamic acid | Oxamidic Ac...)Copy SMILESCopy InChI

Affinity DataKi:  1.38E+5nMAssay Description:Inhibition of human LDHA using pyruvate as substrate assessed as disappearance of NADHMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/4/2020
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL