BDBM22873 1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one::Bactil::CHEMBL305660::Ebastine::Kestine::NCGC00164603

SMILES CC(C)(C)c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1

InChI Key InChIKey=MJJALKDDGIKVBE-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 22873   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 331nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetArachidonate 15-lipoxygenase(Pseudomonas aeruginosa)
University of California Santa Cruz

LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.01E+4nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2016
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 45nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human ABCB1-mediated rhodamine 123 efflux in mouse L5178 cells expressing human MDR1 after 20 mins by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 61nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 47nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.10E+3nMAssay Description:Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataIC50: 920nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

LigandPNGBDBM22873(Bactil | CHEMBL305660 | 1-(4-tert-butylphenyl)-4-[...)
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed