BDBM227589 Radicicol

SMILES C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1

InChI Key InChIKey=WYZWZEOGROVVHK-UHFFFAOYSA-N

Data  4 KI  8 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 227589   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  1.86E+4nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of FTO (unknown origin) (31 to 505 residues) by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to recombinant human HSP90alpha by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  19nMAssay Description:Binding affinity to HSP90 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to recombinant human HSP90 alpha by Surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 19nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetVirulence sensor histidine kinase PhoQ(Salmonella typhimurium (strain LT2 / SGSC1412 / AT...)
Williams College

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  7.15E+5nMAssay Description:Binding affinity to recombinant Salmonella typhimurium 15N-labeled PhoQ catalytic domain (332 to 487 residues) expressed in Escherichia coli XA90 ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistidine kinase(Caulobacter vibrioides)
Williams College

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of recombinant Caulobacter vibrioides cell cycle histidine kinase CckA deltaTM mutant DHp domain (70 to 691 residues) expressed in Escheri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 2.30E+5nMAssay Description:Inhibition of SUMO-tagged PDHK1 (unknown origin) in presence of [gamma-32P]ATP after 30 mins by SDS-PAGE based phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 200nMAssay Description:Inhibition of ATP-ase activity in human colon tumor cell line (HCT116)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 20nMAssay Description:Inhibition of human HSP90More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha [1-236](Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  46.3nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM227589(Radicicol)
Affinity DataIC50: 7.78E+4nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed
TargetATP-citrate synthase(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  7.00E+3nMAssay Description:Non-competitive inhibition of rat liver ACLY using citrate substrate and varying levels of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-citrate synthase(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to rat ACLY assessed as inhibition constant measured after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-citrate synthase(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  1.30E+4nMAssay Description:Non-competitive inhibition of rat liver ACLY using varying levels of citrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetATP-citrate synthase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to ACLY (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed