BDBM213888 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinoxalin-4(5H)-one::TK40

SMILES c1ccc-2c(c1)NC(=O)c3n2c(nn3)S

InChI Key InChIKey=WDUVQRMZWGBWJS-UHFFFAOYSA-N

Data  5 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 213888   

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2D(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >300nM ΔG°: >-8.89kcal/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2A(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi:  560nM ΔG°:  -8.52kcal/mole IC50: 770nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >800nM ΔG°: >-8.31kcal/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >1.30E+3nM ΔG°: >-8.02kcal/mole IC50: 3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Rat)
University of Copenhagen

LigandPNGBDBM213888(TK40 | 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi: >1.80E+5nM ΔG°: >-5.11kcal/mole IC50: 3.00E+5nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed