BDBM209951 US9249124, RK2-017-01

SMILES c1cc(cc(c1)Nc2ccnc(n2)Nc3ccc(cc3)C(=O)N)C(F)(F)F

InChI Key InChIKey=WTPGNNPEEJSILJ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209951   

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM209951(US9249124, RK2-017-01)
Affinity DataIC50: 372nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM209951(US9249124, RK2-017-01)
Affinity DataIC50: 226nMAssay Description:The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)