BDBM209857 US9273052, 19::US9566277, 19

SMILES c1ccc2c(c1)C(=NNC2=O)Cc3ccc(c(c3)C(=O)N4CCn5c(nc(n5)C(F)(F)F)C4)F

InChI Key InChIKey=XJGXCBHXFWBOTN-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 209857   

TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 10.2nMT: 2°CAssay Description:The tested compounds were dissolved in dimethylsulfoxide and then diluted with 1x buffer to the concentration desired in the experiment. 25 uL of a 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 10.2nMT: 2°CAssay Description:he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hansoh Pharmaceutical

US Patent
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)