BDBM20899 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide::CHEMBL252124::Isoxazole, 33

SMILES CCNC(=O)c1noc(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O

InChI Key InChIKey=JXPCDMPJCKNLBY-UHFFFAOYSA-N

Data  3 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 20899   

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM20899(CHEMBL252124 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-...)
Affinity DataIC50: 28nM EC50:  120nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM20899(CHEMBL252124 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-...)
Affinity DataIC50: 28nMAssay Description:Binding affinity to Hsp90 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Qingdao University

Curated by ChEMBL
LigandPNGBDBM20899(CHEMBL252124 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Hsp90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Qingdao University

Curated by ChEMBL
LigandPNGBDBM20899(CHEMBL252124 | 5-(5-chloro-2,4-dihydroxyphenyl)-N-...)
Affinity DataKd:  4.5nMAssay Description:Binding affinity to HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed