BDBM208824 US9266878, 49a

SMILES C[C@@H](C1=Nc2cccc(c2C(=O)N1c3ccccc3)Cl)Nc4c(c(ncn4)N)C#Cc5c[nH]nc5

InChI Key InChIKey=QSVWZWFVMMFIJE-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 208824   

LigandPNGBDBM208824(US9266878, 49a)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM208824(US9266878, 49a)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM208824(US9266878, 49a)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM208824(US9266878, 49a)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:PI3K isoforms were assayed under initial rate conditions in the presence of 25 mM Hepes (pH 7.4), and 2xKm ATP (100-300 uM), 10 uM PIP2, 5% glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM208824(US9266878, 49a)
Affinity DataIC50: 0.300nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)