BDBM207629 US9265734, R01::US9796664, Compound R01

SMILES Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N

InChI Key InChIKey=VOPDXHFYDJAYNS-UHFFFAOYSA-N

Data  5 KI  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 207629   

TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 300nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 230nMAssay Description:Inhibition of human HDAC1 using Acetyl-Lys(Ac)-AMC as substrate measured after 1 hrs by fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 60nMAssay Description:Inhibition of human HDAC1 using Acetyl-Lys(Ac)-AMC as substrate preincubated for 1 hrs followed by substrate addition measured after 1 hrs by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 50nMAssay Description:Inhibition of human HDAC3/NCOR2 using Acetyl-Lys(Ac)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 1 hrs by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1nMAssay Description:Inhibition of human HDAC3/NCOR2 using Acetyl-Lys(Ac)-AMC as substrate measured after 1 hrs by fluorescence release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant full length human HDAC3 expressed in insect Sf9 cells at 10 uM measured after 1 hr by EMSA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 63nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC3/N-terminal GST-tagged human NCOR2 co-expressed in baculovirus infected Sf9 insect cells p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 2.40E+3nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.98E+3nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 2.40E+3nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 300nMAssay Description:Inhibition of human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells preincubated for 2 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells preincubated for 2 hrs followed by Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 expressed in baculovirus infected insect cells preincubated for 2 hrs followed by Fluor-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of HDAC8 (unknown origin) preincubated for 2 hrs followed by Fluor-de-Lys substrate addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged/C-terminal His-tagged HDAC4 expressed in baculovirus infected insect cells preincubated for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged HDAC7 expressed in baculovirus infected insect cells preincubated for 2 hrs followed by Fluor-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 300nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataIC50: 1.98E+3nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Reims Champagne

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin)/NCOR2 (unknown origin) using acetyl-Lys(Ac)-AMC as substrate preincubated for up to 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  5nMAssay Description:Binding affinity to human recombinant HDAC3 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  5nMAssay Description:Binding affinity to human HDAC3 using Acetyl-Lys(Ac)-AMC as substrate assessed as inhibition constant measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  32nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) using acetyl-Lys(Ac)-AMC as substrate preincubated for up to 3 hrs followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM207629(US9265734, R01 | US9796664, Compound R01)
Affinity DataKi:  32nMAssay Description:Binding affinity to human HDAC1 using Acetyl-Lys(Ac)-AMC as substrate assessed as inhibition constant measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed