BDBM205483 US9260417, 6

SMILES CSc1nc(N)cc(Oc2ccc(cc2)-c2nnc(Nc3cccc(c3)C(F)(F)F)[nH]2)n1

InChI Key InChIKey=CMYHZFCJPORPHY-UHFFFAOYSA-N

Data  14 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 205483   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  52nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  170nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetPlatelet-derived growth factor receptor alpha(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  300nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  520nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetCyclin-dependent kinase-like 2(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  5.10E+3nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetCyclin-dependent kinase 11B(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd:  7.50E+3nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetTyrosine-protein kinase ABL1(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetSerine/threonine-protein kinase B-raf(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetSerine/threonine-protein kinase PAK 1(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Amitech Therapeutic Solutions

US Patent
LigandPNGBDBM205483(US9260417, 6)
Affinity DataKd: >1.00E+4nMAssay Description:For the competitive binding assay, test compounds were screened at 10 uM against 70 diverse kinase targets for competitive binding using the KINOMEsc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details
Go to US Patent