BDBM198050 BDBM198051::US9221795, 46

SMILES Cc1c(cncc1F)N2C(=O)c3c(cccc3Cl)N=C2[C@H](C)Nc4c(c(nc(n4)N)N)C#N

InChI Key InChIKey=UISOZEPWNXYPCK-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 198050   

LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 38nMpH: 7.4Assay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human full length PI3K p110alpha/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human full length PI3K p110alpha/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged PI3K p110beta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged PI3K p110beta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 25nMAssay Description:Inhibition of human full length PI3K p110gamma using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM198050(US9221795, 46 | BDBM198051)
Affinity DataIC50: 25nMAssay Description:Inhibition of human full length PI3K p110gamma using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed