BDBM193124 US9193736, 40

SMILES OC(=O)c1ccc(cc1)-c1c(\C=C\c2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1

InChI Key InChIKey=MJTJOIPBOVHNCN-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 193124   

TargetCytochrome P450 2C9(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE9AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human PDE7AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human PDE3BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 2nMpH: 7.8Assay Description:Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
Go to US Patent

LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human PDEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human PDE5AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human PDE1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM193124(US9193736, 40)
Affinity DataIC50: 2nMAssay Description:Human recombinant PDE10A2 was expressed in Sf9 cells, using a recombinant baculovirus construct containing the full length sequence containing a 6 Hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
Go to US Patent