BDBM192712 HG-9-91-01 (1)

SMILES Cc1cccc(c1NC(=O)N(c2ccc(cc2OC)OC)c3cc(ncn3)Nc4ccc(cc4)N5CCN(CC5)C)C

InChI Key InChIKey=UYUHRKLITDJEHB-UHFFFAOYSA-N

Data  16 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 192712   

TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 9.60nMAssay Description:Inhibition of SIK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 6.60nMAssay Description:Inhibition of SIK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 0.920nMAssay Description:Inhibition of SIK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 430nMAssay Description:Inhibition of SIK3 (unknown origin) using ALNRTSSDSALHRRR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 67nMAssay Description:Inhibition of SIK2 (unknown origin) using ALNRTSSDSALHRRR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 250nMAssay Description:Inhibition of SIK1 (unknown origin) using ALNRTSSDSALHRRR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 145nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 9.60nMAssay Description:Inhibition of GST fused recombinant SIK3 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 3.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST fused recombinant SIK1 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 5.84E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of GST fused recombinant SIK3 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 920nMAssay Description:Inhibition of GST fused recombinant SIK1 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataEC50:  220nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed