BDBM191640 US9186318, 9

SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO

InChI Key InChIKey=LYXOBSREVZDKST-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 191640   

TargetHistone deacetylase 2(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 431nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetHistone deacetylase 11(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetPolyamine deacetylase HDAC10(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetHistone deacetylase 9(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 8.94E+3nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 242nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 630nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 630nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 154nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 172nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 119nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 115nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 12nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 31nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Beijing Konruns Pharmaceutical

US Patent
LigandPNGBDBM191640(US9186318, 9)
Affinity DataIC50: 19nMAssay Description:This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent