BDBM18357 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-3,4,5-triol::N-Octyl-DNJ

SMILES CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI Key InChIKey=VGSQNAQYXKTCLP-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18357   

TargetProtein-lysine 6-oxidase(Human)
Hokuriku University

LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 2.10E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of maltase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetBeta-galactosidase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of lactase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSucrase-isomaltase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 750nMAssay Description:Inhibition of sucrase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM18357((2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-...)
Affinity DataKi:  420nM ΔG°:  -9.04kcal/mole IC50: 820nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed