BDBM18129 (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid::L-[U-14C]Tyr::Tyrosine::US11021454, Compound L-tyr::US20240415800, Compound 2-2 (Tyr)

SMILES c1cc(ccc1C[C@@H](C(=O)O)N)O

InChI Key InChIKey=OUYCCCASQSFEME-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18129   

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50: 6.80E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
China Pharmaceutical University

US Patent
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50: 6.00E+4nMAssay Description:11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
Go to US Patent

TargetGlutamate carboxypeptidase 2(Human)
The Johns Hopkins University

US Patent
LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition potencies against GCPII (IC50 values) were determined using previously described methods with minor modification. Rojas et al., 2002. Brie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

TargetTubulin--tyrosine ligase(Human)
Binghamton University

LigandPNGBDBM18129((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...)
Affinity DataKi:  2.50E+4nM ΔG°:  -6.53kcal/molepH: 6.8 T: 2°CAssay Description:Inhibition of [3H]-L-tyrosine incorporation into tubulin by enzyme tubulin tyrosine ligase (TTL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed