BDBM17947 (2R,4S,5S,7R)-5-amino-N-butyl-4-hydroxy-8-{[2-(3-methoxypropoxy)phenyl]formamido}-2,7-dimethyloctanamide::Renin nonpeptide inhibitor, 7

SMILES CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H](N)C[C@@H](C)CNC(=O)c1ccccc1OCCCOC

InChI Key InChIKey=HCEVFKSMFFEYMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17947   

TargetRenin(Human)
Novartis Pharmaceuticals

LigandPNGBDBM17947((2R,4S,5S,7R)-5-amino-N-butyl-4-hydroxy-8-{[2-(3-m...)
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed
TargetPepsin A(Pig)
Novartis Pharmaceuticals

LigandPNGBDBM17947((2R,4S,5S,7R)-5-amino-N-butyl-4-hydroxy-8-{[2-(3-m...)
Affinity DataIC50: 1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed