BDBM17697 2-aminobenzoxazole, 22::4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide

SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1

InChI Key InChIKey=KMNCFOUKJYOZIF-UHFFFAOYSA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 17697   

LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 720nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 3.18E+3nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 4.01E+3nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 1.14E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 4.37E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 4.00E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataIC50: 4.00E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17697(4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]...)
Affinity DataKi:  2.80nM ΔG°:  -11.5kcal/mole IC50: 4.60nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed