BDBM17297 4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl)methyl]-1H-1,3-benzodiazol-2-yl}methyl)amino]benzene-1-carboximidamide::BIBR1109

SMILES [H]/N=C(/c1ccc(cc1)NCc2nc3cc(ccc3n2C)Cn4c(nc5c4cccc5)C)\N

InChI Key InChIKey=IRKPNOLLMNHSOU-UHFFFAOYSA-N

Data  8 KI

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 17297   

TargetCoagulation factor X(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  40nM ΔG°:  -10.5kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine protease 1(Bovine)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  67nM ΔG°:  -10.2kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  780nM ΔG°:  -8.66kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XI(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  4.10E+3nM ΔG°:  -7.64kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetPlasminogen(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  9.20E+3nM ΔG°:  -7.14kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  1.60E+4nM ΔG°:  -6.80kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >4.00E+4nM ΔG°: >-6.24kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >5.00E+4nM ΔG°: >-6.10kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed