BDBM17281 7-({2-[(1-ethanimidoylpiperidin-4-yl)oxy]-9H-carbazol-9-yl}methyl)naphthalene-2-carboximidamide::CHEMBL369251::Naphthylamidine template, II::ZK-806450

SMILES [H]/N=C(/C)\N1CCC(CC1)Oc2ccc3c4ccccc4n(c3c2)Cc5ccc6ccc(cc6c5)C(=N)N

InChI Key InChIKey=DZLGSWPXZYDHBD-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17281   

TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17281(ZK-806450 | 7-({2-[(1-ethanimidoylpiperidin-4-yl)o...)
Affinity DataKi:  1.60nM ΔG°:  -11.9kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17281(ZK-806450 | 7-({2-[(1-ethanimidoylpiperidin-4-yl)o...)
Affinity DataKi:  1.60nMAssay Description:In vitro inhibition of human Coagulation factor X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Berlex

LigandPNGBDBM17281(ZK-806450 | 7-({2-[(1-ethanimidoylpiperidin-4-yl)o...)
Affinity DataKi:  36nM ΔG°:  -10.0kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2007
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17281(ZK-806450 | 7-({2-[(1-ethanimidoylpiperidin-4-yl)o...)
Affinity DataKi:  40nMAssay Description:In vitro inhibition of bovine trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17281(ZK-806450 | 7-({2-[(1-ethanimidoylpiperidin-4-yl)o...)
Affinity DataKi:  40nMAssay Description:In vitro inhibition of human Coagulation factor II.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed