BDBM17053 BX-320::N-(3-{[5-bromo-2-({3-[(pyrrolidin-1-ylcarbonyl)amino]phenyl}amino)pyrimidin-4-yl]amino}propyl)-2,2-dimethylpropanediamide::N-{3-[(5-bromo-2-{[3-(pyrrolidin-1-ylcarbonylamino)phenyl]amino}pyrimidin-4-yl)amino]propyl}-2,2-dimethylpropanediamide
SMILES CC(C)(C(=O)N)C(=O)NCCCNc1c(cnc(n1)Nc2cccc(c2)NC(=O)N3CCCC3)Br
InChI Key InChIKey=ZNSULAZTNWFKEW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 17053
Affinity DataIC50: 39nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant PDK1 assessed as PtdIns-3,4-P2-mediated AKT2 activation using biotin-ARRRDGGGAQPFRPRAATF as substrate after 2 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of PDK1 using [gamma33P]-ATP as substrate after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of N terminal His-tagged human recombinant PDK1 using H2NARRRGVTTKTFCGT peptide as substrate assessed as substrate phosphorylation after 4...More data for this Ligand-Target Pair