BDBM170514 US9085540, 54

SMILES CCc1c(nc(c(n1)C(=O)N)Nc2ccc(cc2)N3CCC(CC3)N4CCN(CC4)C)O[C@@H]5CCN(C5)C(=O)C=C

InChI Key InChIKey=QKDCLUARMDUUKN-UHFFFAOYSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 170514   

TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 1.70nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 4.5nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19/T790M double mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50: 230nMAssay Description:Inhibition of wild type EGFR in human NCI-H1666 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)