BDBM17015 (3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::CHEMBL86755::Indolinone based inhibitor, 1::Oxindole I

SMILES O=C1Nc2ccccc2\C1=C\c1ccc[nH]1

InChI Key InChIKey=SEZFNTZQMWJIAI-UHFFFAOYSA-N

Data  15 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 17015   

TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 350nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataKd:  361nMAssay Description:Binding affinity to human SRPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataKd:  353nMAssay Description:Binding affinity to human DRAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 140nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-972]()
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 390nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.20E+4nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.80E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-678,753-922](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-678,753-922](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed