BDBM165396 US8168651, Compound TABLE 16.64::US9062043, Table 13, Compound 100::US9062043, Table 13, Compound 64::US9062043, Table 20b, Compound 29

SMILES c1cc(cc(c1)Nc2c3c(cnc(n3)NC4CC4)c5ccc(cc5n2)C(=O)O)C(F)(F)F

InChI Key InChIKey=UXZATHOFDZQOMY-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 165396   

TargetCasein kinase II subunit alpha(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM165396(US9062043, Table 20b, Compound 29 | US9062043, Tab...)
Affinity DataIC50: 10nMpH: 7.4Assay Description:The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM165396(US9062043, Table 20b, Compound 29 | US9062043, Tab...)
Affinity DataIC50: 9nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM165396(US9062043, Table 20b, Compound 29 | US9062043, Tab...)
Affinity DataIC50: 750nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
Senhwa Biosciences

US Patent
LigandPNGBDBM165396(US9062043, Table 20b, Compound 29 | US9062043, Tab...)
Affinity DataIC50: 9nMAssay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM165396(US9062043, Table 20b, Compound 29 | US9062043, Tab...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)