BDBM16512 (2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2-carboxamide::(2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chromene-4,4-imidazolidine]-2-carboxamide::CHEMBL84446::Fidarestat::Fidarestat (1)
SMILES NC(=O)[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(F)ccc2O1
InChI Key InChIKey=WAAPEIZFCHNLKK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 16512
Affinity DataKd: 16nMpH: 8.5Assay Description:The anti-His antibody (His Capture Kit, GE Healthcare) was immobilized on sensor chip CM5 (GE Healthcare), in a Biacore T200 or Biacore S200 instrume...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Tested for in vitro inhibition activity against human Aldose reductase (human AR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Human)
Rational Drug Design Laboratories
Curated by ChEMBL
Rational Drug Design Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Tested for in vitro inhibition activity against human aldehyde reductase (AHR)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Binding affinity for human Aldose reductase 2 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against human ALR2More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Pig)
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Human)
Rational Drug Design Laboratories
Curated by ChEMBL
Rational Drug Design Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 by spectrophotometric analysisMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 16512
CellAldose Reductase (ALR2) Mutant (L300P)(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
ITC DataΔG°: -9.29kcal/mole −TΔS°: 7.10kcal/mole ΔH°: -16.4kcal/mole logk: 6.50E+6
pH: 8.0 T: 24.85°C
pH: 8.0 T: 24.85°C
ITC DataΔG°: -11.2kcal/mole −TΔS°: 6.88kcal/mole ΔH°: -18.0kcal/mole logk: 1.53E+8
pH: 8.0 T: 24.85°C
pH: 8.0 T: 24.85°C