BDBM163619 UF010::US10807944, Compound UF010::US11731934, Compound UF010

SMILES CCCCNNC(=O)c1ccc(Br)cc1

InChI Key InChIKey=BVQCFCYPFJOOAV-UHFFFAOYSA-N

Data  50 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 163619   

TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of recombinant human HDAC6 using fluorescent as substrate measured for 10 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected sf9 cells using Boc-Lys(trifluoroacetyl)-AMC)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected sf9 cells using Boc-Lys(trifluoroacetyl)-AMC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 expressed in baculovirus infected sf9 cells using p53 (379 to 382 residues) (Arg-His-Lys(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged HDAC10 (2 to 631 residues) expressed in baculovirus infected sf9 cells using p53 (379 to 382 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of recombinant human HDAC11 expressed in baculovirus infected sf9 cells using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of recombinant human HDAC1 using fluorescent as substrate measured for 15 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 322nMAssay Description:Inhibition of recombinant human HDAC2 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 257nMAssay Description:Inhibition of recombinant human HDAC3 using fluorescent as substrate measured for 15 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of recombinant human HDAC8 using fluorescent as substrate measured for 10 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human HDAC4 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human HDAC5 using fluorescent as substrate measured for 30 mins by fluorescence based microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human HDAC5 using Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 500nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 9.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 460nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.33E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 190nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 100nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 60nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.50E+3nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 9.10E+3nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.53E+4nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 4.45E+4nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 460nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.33E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 500nMpH: 8.0Assay Description:Activity against HDACs 1 to 11 was assessed by using an acetylated 7-amino-4-methylcoumarin (AMC)-labeled peptide substrate. A substrate based on res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 9.09E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 2.83E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 500nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 100nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 60nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.50E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 9.10E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 500nMAssay Description:Inhibition of HDAC1 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 cells using p53 (379 to 382 residues) (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human C-terminal His-tagged HDAC3 (1 to 428 residues)/human N-terminal GST-tagged NcoR2 (395 to 489 residues) expressed in sf9 cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Birla Institute of Technology and Science-Pilani Hyderabad Campus

Curated by ChEMBL
LigandPNGBDBM163619(UF010 | US10807944, Compound UF010 | US11731934, C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed