BDBM16219 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine::pyrazole-based inhibitor 9

SMILES Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1

InChI Key InChIKey=LZMOSYUFVYJEPY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 16219   

LigandPNGBDBM16219(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM16219(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Affinity DataIC50: 32nMAssay Description:Inhibition of PKBalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM16219(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Affinity DataIC50: 47nMAssay Description:Inhibition of PKBgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM16219(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PKBbeta (unknown origin) using (HARKRERTYSFGHHA) as substrate incubated for 4 hoursMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM16219(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed