BDBM15940 Aminopyridine-Based Inhibitor 6t::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-bromo-2,5-dimethoxyphenyl)acetamide

SMILES CCOc1c(c(cc(n1)NC(=O)Cc2cc(c(cc2OC)Br)OC)N)C#N

InChI Key InChIKey=GKODDLYLEKSDJL-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15940   

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15940(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-brom...)
Affinity DataIC50: 77nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15940(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-brom...)
Affinity DataIC50: 160nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed