BDBM152720 N-[3-({[(3S,5S)-5-({[3-(thiophene-2-imidamido)phenyl]methoxy}methyl)pyrrolidin-3-yl]oxy}methyl)phenyl]-2H-1λ⁴-thiophene-2-carboximidamide (25)::US9242957, QJ-II-199
SMILES [H]/N=C(/c1cccs1)\Nc2cccc(c2)COC[C@@H]3C[C@@H](CN3)OCc4cccc(c4)N/C(=N\[H])/c5cccs5
InChI Key InChIKey=GPVRORSBZUBDJB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 152720
TargetNitric oxide synthase oxygenase(Bacillus subtilis (strain 168))
University of California Irvine
University of California Irvine
Affinity DataKd: 1.10E+4nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 21.4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of rat nNOS using L-arginine substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.23E+3nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Affinity DataKi: 1.45E+3nMAssay Description:Inhibition of bovine eNOS using L-arginine substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.11E+3nMAssay Description:Inhibition of mouse macrophage iNOS using L-arginine substrateMore data for this Ligand-Target Pair
Affinity DataKi: 3.17E+3nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair