BDBM15210 CHEMBL148333::H-8::Lopac-M-9656::N-(2-methylaminoethyl)isoquinoline-5-sulfonamide::N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide

SMILES CNCCNS(=O)(=O)c1cccc2c1ccnc2

InChI Key InChIKey=PJWUXKNZVMEPPH-UHFFFAOYSA-N

Data  3 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 15210   

TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataIC50: 7.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataIC50: 5.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of Plasmodium falciparum PfmrkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase(Rabbit)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory constant against cAPK (PKA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMyosin light chain kinase, smooth muscle(Chicken)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibitory constant against MLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha (Human)
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataKi:  9.50E+5nMAssay Description:Inhibitory constant against CK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed