BDBM149993 US8975417, 49

SMILES Cc1c2c(n(n1)C3CC3)C(=O)N([C@@H]2c4ccc(cc4)Cl)C5=CN(C(=O)C(=C5)C)C

InChI Key InChIKey=PXGREUPWZAUELV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 149993   

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM149993(US8975417, 49)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM149993(US8975417, 49)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM149993(US8975417, 49)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM149993(US8975417, 49)
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent