BDBM14974 CHEMBL221484::N-(3-(3-(Dimethylamino)propyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide::N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}benzamide::pyridinyl pyrimidine 39

SMILES CN(C)CCCc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ccncn3)c2)cc(c1)C(F)(F)F

InChI Key InChIKey=OHHGYJBFPVJURR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14974   

TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 2nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed