BDBM148173 US8962616, 1

SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncco1)c1ccc(F)cc1F

InChI Key InChIKey=ITDPHYUDGLCWQU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 148173   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 511nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Pfizer

US Patent
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 619nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 614nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 7.49E+4nMAssay Description:Inhibition of CatD (unknown origin) assessed as fluorescence polarization by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 330nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM148173(US8962616, 1)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1 (unknown origin) using Biotin-GLTNIKTEEISEISYEVEFR-C[oregon green]KK-OH substrate assessed as fluorescence polarization by cell f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed