BDBM14362 6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one::6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one::CI 930::CI-930

SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1

InChI Key InChIKey=AEZZPAQOEUQNBB-UHFFFAOYSA-N

Data  5 KI  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 14362   

LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against cAMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 3.40E+6nMAssay Description:Inhibition of fraction I of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 600nMAssay Description:Inhibition of fraction III of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of phosphodiesterase (PDE I).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 260nMAssay Description:In vitro inhibition of phosphodiesterase (PDE III).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 900nMAssay Description:Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 600nMAssay Description:Inhibition of cAMP PDE III enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cAMP PDE I enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 4.60E+5nMAssay Description:Inhibition of cAMP PDE II enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition cGMP PDE I enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against cGMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 600nMAssay Description:Inhibitory concentration against cAMP PDE III enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibitory concentration against cGMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of fraction II of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 4.60E+5nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 4.60E+5nMAssay Description:Inhibition of cGMP PDE II enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of phosphodiesterase (PDE V).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataKi: >5.00E+4nM ΔG°: >-5.80kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataKi: >5.00E+4nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataKi: >5.00E+4nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataKi: >5.00E+4nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14362(CI 930 | 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-2...)
Affinity DataKi: >5.00E+4nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed