BDBM14360 (-)-1::(R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)phenyl]-2-[5-(2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoro)ethyl)thiazolyl]ethyl}pyridine N-Oxide::3-[(2R)-2-[3-cyclopropoxy-4-(difluoromethoxy)phenyl]-2-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]ethyl]-1-oxidopyridin-1-ium::L-869299

SMILES c1cc(c[n+](c1)[O-])C[C@H](c2ccc(c(c2)OC3CC3)OC(F)F)c4ncc(s4)C(C(F)(F)F)(C(F)(F)F)O

InChI Key InChIKey=SPOLCPORTSDTGD-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14360   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of North Carolina At Chapel Hill

LigandPNGBDBM14360((R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)p...)
Affinity DataIC50: 56nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
University of North Carolina At Chapel Hill

LigandPNGBDBM14360((R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)p...)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
University of North Carolina At Chapel Hill

LigandPNGBDBM14360((R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)p...)
Affinity DataIC50: 135nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
University of North Carolina At Chapel Hill

LigandPNGBDBM14360((R)-(-)-3-{2-[(3-cyclopropyloxy-4-difluromethoxy)p...)
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)