BDBM14170 APC-7377::Benzo[b]thiophene-2-carboxamidine::[amino(1-benzothiophen-2-yl)methylidene]azanium

SMILES c1ccc2c(c1)cc(s2)C(=[NH2+])N

InChI Key InChIKey=JZWDLUGQTRKBNA-UHFFFAOYSA-O

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14170   

TargetSerine protease 1(Bovine)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  1.00E+3nM ΔG°:  -8.10kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  2.30E+3nM ΔG°:  -7.61kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  9.90E+3nM ΔG°:  -6.75kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  1.50E+4nM ΔG°:  -6.51kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  2.10E+4nM ΔG°:  -6.31kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14170(Benzo[b]thiophene-2-carboxamidine | [amino(1-benzo...)
Affinity DataKi:  5.80E+4nM ΔG°:  -5.72kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed